Seeking Health HomocysteX Plus, 60 ct

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Seeking Health HomocysteX Plus supplies bioactive forms of four essential B-Vitamins together with betaine (also known as trimethlglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. 

This formula is exceptional for those with defective MTHFR genes.  60 veg caps. 

Product Details

Seeking Health Homocystex Plus, 60 veg caps

Homocystex Plus takes the four essential B complex vitamins from Homocystex and adds vitamin B2 and betaine (as trimethylglycine as TMG). 

The body’s methylation process is vital for formation of essential cell components such as proteins, the nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes.  Methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite.

Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body. To nutritionally support optimal methylation capacity, HomocysteX Plus supplies folate, vitamins B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body.

Helps maintain normal homocysteine metabolism

Optimizing homocysteine metabolism can play an important role in maintaining healthy cardiovascular and cognitive functions. Homocysteine can either be converted to the amino acid cysteine through a series of vitamin B6-dependent reactions or converted to the essential amino acid methionine through a methylation reaction involving folate and vitamin B12.

HomocysteX Plus supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations, which is why Homocystex Plus provides these other ingredients to help lower homocysteine and support the methylation cycle.

Supports methylation processes

Most methylation reactions involve the molecule S-adenosylmethionine (SAM) as a methyl group donor. Thus, supporting the formation of SAM can be a viable approach to supporting methylation processes.

Folate and vitamin B12 support methylation capacity, as they are essential players in the pathway that produces SAM. Vitamin B2 and betaine also play various different roles to help ensure adequate SAM production, whereas vitamin B6 contributes to methylation processes by facilitating the formation of methyl groups. For optimal nutrient absorption and utilization, this product provides biologically active forms of folate (as Metafolin® ** L-5-methyltetrahydrofolate) and vitamin B12 (as methylcobalamin). These forms are already fully "active” and readily usable, as they do not require further metabolism in the body. Active forms of vitamin B2 (as riboflavin 5’-phosphate) and vitamin B6 (as pyridoxal 5’-phosphate) are also provided for highest absorption and bio-availability.

Some individuals are more susceptible to homocysteine accumulation as they are unable to fully convert common forms of folate (such as oxidized folic acid) and B12 (such as cyanocobalamin) into their active forms. In contrast, providing folate and vitamin B12 in their active, methylated forms provides a reliable approach to supporting homocysteine metabolism. Betaine also assists homocysteine regulation through an alternative pathway in which it supplies important methyl groups that allow homocysteine to be safely converted to methionine.

Suggested Use: 1 capsule daily with food. 60 veg caps


About Seeking Health, the company

Dr. Ben Lynch, founder and Chief Medical Officer of Seeking Health, is a naturopathic physician. While majoring in Cell and Molecular biology at the University of Washington, Dr. Ben took a trip through the South Pacific and Southeast Asia that changed his outlook on traditional medicine, and his life.

During this trip, Dr. Ben hiked through the forests, mountains and coasts of Tasmania, worked a cattle ranch in the Outback of Australia, and volunteered with Mother Theresa in Calcutta. He lived in Fiji with a family having no electricity or plumbing, experienced the Himalayan Mountains of Northern India, worked a fruit orchard in New Zealand, and returned to America with an impression of a different form of medicine than he had ever experienced with his mainstream medical education.

This profound experience led Dr. Ben to Bastyr University, and he studied the Mind-Body Connection, Environmental Medicine, Functional Medicine, and Epigenetics.

Dr. Ben saw the huge need for people to obtain foundational nutrients, and Seeking Health was born. Without foundational nutrients, biochemical dysfunction occurs and causes symptoms. Doctor after doctor and person after person do not understand the absolute requirement for our bodies to have the tools to maintain function.

  • Without water, we die.
  • Without food, we die.
  • Without probiotics, we get digestive disorders.
  • Without multivitamins, we become depressed, fatigued and sick.

“If one supports their bodily systems, especially their digestion and mental health, with pure, highly absorbable, well-formulated nutrients, the ability to remain healthy and vital significantly increases. We want your foundation rock solid and we provide the tools to do so.”

-Dr. Ben Lynch, founder of Seeking Health

Seeking Health believes that the root cause for many health conditions and supplements stem from ineffective digestion, environmental exposures, poor diet, and lack of a healthy social outlet and inlet.

  • Once digestion is restored and optimized with the best probiotics, digestive enzymes, stomach acid and intestinal repair nutrients, one is able to absorb nutrients from foods and high quality multivitamins.
  • Once environmental exposures are reduced, one is able to reduce toxic burden which then frees up nutrients to work in promoting health and preventing disease.
  • Once diet is optimized, nutrients flood in, energy increases, blood sugar stabilizes and the immune system balances.
  • Creating a social outlet and inlet allows the parasympathetic nervous system to regain control over the reactive sympathetic nervous system, allowing countless nutrients to be used proactively and in a protective manner instead of being wasted on producing stress hormones.

Seeking Health is here to see you get better, and stay better. Their true passion is prevention.

Seeking Health is based in Bellingham, Washington and operated and managed by a team dedicated to bringing you better health through the best quality supplements, prebiotics, probiotics, and multivitamins.

Seeking Health brings you effective formulas produced without preservatives, colors, titanium dioxide, coloring, or gluten.

Label Information


Other Ingredients
Vegetarian capsule (hydroxypropyl methylcellulose, water), cellulose, L-leucine, and silicon dioxide.
Suggested use
1 capsule daily with food or as directed by your physician. May be combined with L-5-MTHF 1000 by Seeking Health should additional methylated folate be required.
Keep Out Of Reach Of Children
Serving size
1 Vegetarian capsules
Servings per package
60 Vegetarian capsules
Refrigeration Recommended
Use Ice Pack
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