When it comes to immune supplement support, very few proprietary formulations are scientifically tested for efficacy. The Chief Science Officer and Registered Dietitian at Healthy Goods created ImmunoZinc in 2020 based on research showing the importance of combining zinc with a zinc ionophore to maximize immune function.

After formulating ImmunoZinc, the product was rigorously evaluated using computational assessment by CytoSolve, a global leader in systems biology research. This powerful technology integrates data from thousands of peer-reviewed studies to map complex biochemical pathways, examine how specific nutrients influence cellular and molecular processes in the immune system, and identify synergistic effects among ingredients.

Through CytoSolve's analysis, ImmunoZinc was tested for its potential to support immune balance, normal inflammatory signaling, and overall cellular resilience.

Cytosolve: Computational Science Meets Nutrition

Using CytoSolve’s in silico modeling, researchers simulated how ImmunoZinc's key nutrients influence specific molecular pathways involved in immune function:

• TLR4 signaling: A key component of immune communication. Zinc, quercetin, bromelain, and EGCG were all shown to modulate three key immune biomarkers— IL-1β, IL-6, and TNF-α — within the TLR4 pathway, helping maintain balanced immune signaling. 

• PD-L1/PD-1 pathways: These pathways regulate immune cell responsiveness. Per CytoSolve analysis, quercetin demonstrated a particularly strong influence here, lowering PD-L1 expression and supporting healthy immune cell activation.

• Viral Endocytosis and Viral Replication: This includes pathways related to viral RNA and RNA-dependent RNA polymerase (RdRP). CytoSolve analysis found that copper, zinc, and quercetin affected biomarkers associated with the viral life cycle, inhibiting both viral entry and replication.

• Zinc-Quercetin Ionophore Pathway: This mechanism plays a critical role in zinc's antiviral activity by increasing zinc influx into cells. Studies have shown that high intracellular zinc concentrations, when paired with a zinc ionophore, inhibit replication of several RNA viruses, including the influenza virus, respiratory syncytial virus, and various picornaviruses.
  

The findings prove that these nutrients in ImmunoZinc work synergistically to help regulate inflammatory messengers and support balanced immune responses at the cellular level.

The Power of Nutrient Synergy

ImmunoZinc combines five bioactive ingredients, including zinc (as zinc citrate), copper (as copper lysinate), quercetin, bromelain, and epigallocatechin gallate (EGCG from decaf green tea extract). CytoSolve analysis found that each ingredient contributes to distinct yet complementary mechanisms related to immune function.

Here's a summary of the ingredient interactions per CytoSolve analysis.  

Zinc modulates the immune response by downregulating the NF-kB pathway, thereby limiting the production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. Zinc also reduces nitric oxide production, which has been implicated in immune dysfunction. A 30 mg dose decreased IL-6 and TNF-α the most.

Quercetin is a zinc ionophore, helping zinc move into cells where it supports immune and antioxidant defense. According to CytoSolve analysis, quercetin exhibited the most significant impact on immunity in ImmunoZinc. It was shown to lower cytokines, reducing PD-L1 expression, and inhibiting viral entry and replication in lung epithelial cells. Quercetin also blocks viral RNA polymerase. CytoSolve concluded that the 1.5 grams of quercetin in ImmunoZinc is very effective.

Bromelain demonstrates anti-inflammatory properties. Demonstrates immune-modulating properties by regulating cytokines such as IL-1, IL-6, and TNF-α, supporting a balanced immune function and tissue comfort. 

Copper maintains an optimal zinc-to-copper ratio essential for cellular energy and defense. In CytoSolve analysis, copper displayed anti-viral properties, reducing viral load, interfering with replication, and blocking RdRP

The Future of Nutrition-Backed Formulation

What sets ImmunoZinc apart is its foundation in both biochemistry and data-driven modeling. This approach goes beyond traditional formulation by examining how nutrients behave together in real biological systems, paving the way for smarter, evidence-informed supplementation.

In short, ImmunoZinc represents a new frontier in nutritional design—rooted in research, guided by computational analysis, and formulated to support immune health through nutrient synergy.

Try ImmunoZinc now and feel the science of smarter immune support.

Kelly Harrington, MS, RD

Registered Dietitian for Healthy Goods

References: